Quality sample processing should be carried out in order to achieve good tissue and cellular structures visualization. Histological and cytological tissue sample processing consists of a few steps, and one of them includes infiltration and embedding the sample into the paraffin and making paraffin tissue blocks. This procedure is being conducted in the following manner: the properly oriented sample (depending on the type of tissue) is positioned on the central part of the mold, specifically used in histology. After pouring melted paraffin (embedding the sample), it is necessary to cool it down as soon as possible in order to avoid creating paraffin crystals that influence the sample sectioning quality. The cooled and hardened paraffin block must be removed from the mold, which can be a complicated procedure, and can also cause the block to crack. Using BioGnost’s DeMold Spray by applying it to the mold before inserting the sample and pouring the paraffin, the tissue block is removed quickly and simply and can be prepared for microtome sectioning and for further processing and analysis.